This thesis contains three main chapters that explore various issues related to natural resources, climate change and long-term economic growth. In Chapter 2, we examine the conditions under which endogenous long-term economic growth will emerge in an overlapping-generation model with productive non-renewable resources. We formally prove that the elasticity of substitution between labour and natural resource input plays a crucial role in generating endogenous long-term economic growth. In Chapter 3, we examine how the substitutability between renewable and non-renewable resources will affect long-term economic growth. To achieve this, we develop two discrete-time endogenous growth models with both renewable and non-renewable natural resourc...