Humani serumski albumin - najvažniji transportni protein u krvi

Human serum albumin (HSA) is the most abundant protein in human serum. It bas numerous functions, one of which is transport of small hydrophobic molecules, such as metabolites, hormones, and nutrients, as well as drugs and toxins. This promiscuous, nonspecific affinity can !cad to competition and displacement of different ligand in binding to HSA and cause increase in toxicity of displaced ligands. In this paper, the most important HSA binding sites are described and the risk of displacement interactions between different ligands is discused. W hile such interactions are more common between physiological (e.g. fatty acids, bilirubin, heme etc) and patophysiological ligands (e.g. indoxyl sulfate, indol-3-acetate, hypuric acid, and CMPF) and drugs, displacement interactions between drugs are also known. In certain cases these interactions can direct!y influence drug's free, active concentration in blood