Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection
- Guergnon, J.
- Dalmasso, C.
- Broet, P.
- Meyer, L.
- Westrop, S. J.
- Imami, N.
- Vicenzi, E.
- Morsica, G.
- Tinelli, M.
- Poma, B. Zanone
- Goujard, C.
- Potard, V.
- Gotch, F. M.
- Casoli, C.
- Cossarizza, A.
- Macciardi, F.
- Debré, P.
- Delfraissy, J. F.
- Galli, M.
- Autran, B.
- Costagliola, D.
- Poli, G.
- Theodorou, I.
- Riva, A.
- Consortium, G. I. S. H. E. A. L.
DOIAbstract
International audienceWe performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, = 4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype
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