Add to ORKGLittle is known of the exact sequence of events that occur in the processing of exogenously derived antigen for presentation via major histocompatability class II (MHCII) antigens. Proteolytic enzymes, namely cathepsin proteinases, are responsible for degrading endocytosed antigen in specific intracellular compartments of antigen presenting cells (APC). It is still unclear how such a wide variety of peptides can be generated from a single antigen and in such a way that a hierarchy of immunogenicity exists amongst these peptides. The gastrointestinal epithelium is among the non-lymphoid tissues implicated as having the potential to process and present antigen. How the processing of exogenous antigen by 'non-professional' APC such as these re...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
The adaptive immune response depends on the creation of suitable peptides from foreign antigens for ...
The adaptive immune response depends on the creation of suitable peptides from foreign antigens for ...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Proteases perform two key roles in the class II MHC antigen processing pathway. They initiate remova...
Major histocompatibility complex class I (MHC-1) molecules bind peptide fragments derived from cytos...
Major histocompatibility complex class I (MHC-1) molecules bind peptide fragments derived from cytos...
Major histocompatibility complex class I (MHC-1) molecules bind peptide fragments derived from cytos...
To address the role of different proteases in degradation of antigen destined for MHC class II-restr...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
The adaptive immune response depends on the creation of suitable peptides from foreign antigens for ...
The adaptive immune response depends on the creation of suitable peptides from foreign antigens for ...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Although the endpoint of the class II antigen-processing pathway is well characterized, the processi...
Proteases perform two key roles in the class II MHC antigen processing pathway. They initiate remova...
Major histocompatibility complex class I (MHC-1) molecules bind peptide fragments derived from cytos...
Major histocompatibility complex class I (MHC-1) molecules bind peptide fragments derived from cytos...
Major histocompatibility complex class I (MHC-1) molecules bind peptide fragments derived from cytos...
To address the role of different proteases in degradation of antigen destined for MHC class II-restr...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the in...
The adaptive immune response depends on the creation of suitable peptides from foreign antigens for ...
The adaptive immune response depends on the creation of suitable peptides from foreign antigens for ...