Effect of dietary anthocyanins on biomarkers of oxidative stress and antioxidative capacity: A systematic review and meta-analysis of randomized controlled trials

In this study, the efficacy of dietary anthocyanins (ACs) on indices of oxidative stress and antioxidative capacity was evaluated through a meta-analytical approach. meta-analysis of 23 trials indicated that ACs significantly reduced the levels of malondialdehyde (MDA; −0.41, 95% CI: −0.62 to −0.21, P < 0.001), oxidized low-density lipoprotein (Ox-LDL; −0.27, 95% CI: −0.55 to 0.02, P = 0.064), and isoprostane (−0.57, 95% CI: −0.78 to −0.36, P < 0.001) while significantly increased the level of total antioxidative capacity (TAC; 0.32, 95% CI: 0.08 to 0.55, P = 0.008) and activity of superoxide dismutase (SOD; 0.29, 95% CI: 0.07 to 0.51, P = 0.010) and glutathione peroxidase (GPx; 0.59, 95% CI: 0.19 to 1.0, P = 0.004). Compared to healthy subjects, ACs were more useful for unhealthy subjects because of the significant decrease in MDA, Ox-LDL, and isoprostane levels; and significant increase in TAC level and SOD activity. The overall results indicate that dietary ACs alleviate oxidative stress and enhance antioxidative capacity in the subjects. Keywords:Anthocyanins, Antioxidant, Oxidative stress, Antioxidative capacity, Antioxidative defense, Meta-analys