THE STUDY OF CELLULAR FACTORS OF IMMUNITY IN PATIENTS WITH NON-HODGKIN'S LYMPHOMAS

The purpose of this study was to study the basic cellular indicators of immunity in patients with non-Hodgkin's lymphomas to substantiate the immunopathogenetic features of the course of the disease. It turned out to be important that patients were divided into 2 groups with virus carrier and without virus carrier.An analysis of the results allowed us to identify pronounced changes in the cellular immunity that manifested themselves by suppressing the expression of CD3 +, CD3 + CD4 +, IRI, against this background, an increase in the expression of CD3 + CD8 +, CD16 + and CD20 + B cells, as well as increased expression of activation molecular markers of CD38 + lymphocytes, CD95 +. Deep T-cell immunodeficiency was detected against the background of pathological activation of lymphocytes, which is clinically often reflected by frequent relapses, an unfavorable course of the disease, and treatment results.The purpose of this study was to study the basic cellular indicators of immunity in patients with non-Hodgkin's lymphomas to substantiate the immunopathogenetic features of the course of the disease. It turned out to be important that patients were divided into 2 groups with virus carrier and without virus carrier.An analysis of the results allowed us to identify pronounced changes in the cellular immunity that manifested themselves by suppressing the expression of CD3 +, CD3 + CD4 +, IRI, against this background, an increase in the expression of CD3 + CD8 +, CD16 + and CD20 + B cells, as well as increased expression of activation molecular markers of CD38 + lymphocytes, CD95 +. Deep T-cell immunodeficiency was detected against the background of pathological activation of lymphocytes, which is clinically often reflected by frequent relapses, an unfavorable course of the disease, and treatment results