Apoptosis, pyroptosis and necroptosis contribute to host protection against diverse pathogens, but their interplay and the underlying molecular mechanisms coordinating their interactions have not yet been resolved (Green, 2019). To define the relative importance of these cell death pathways and their inter-connectivity in host defence, we deleted caspases-1/-11/-12/-8 and RIPK3 in varying combinations to generate mice lacking pyroptosis, death receptor-induced apoptosis and/or necroptosis, and subjected them to Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. The loss of each cell death pathway alone had only minor impact on pathogen control but the combined absence of pyroptosis, caspase-8 mediated apoptosis and necropto...