BACKGROUND: Why some but not all patients with severe aortic stenosis (SevAS) develop otherwise unexplained reduced systolic function is unclear. We investigate the hypothesis that reduced creatine kinase (CK) capacity and flux is associated with this transition. METHODS: We recruited 102 participants to 5 groups: moderate aortic stenosis (ModAS) (n=13), SevAS, left ventricular (LV) ejection fraction ≥55% (SevAS-preserved ejection fraction, n=37), SevAS, LV ejection fraction 0.99). Accompanying the fall in CK flux, total CK and citrate synthase activities and the absolute activities of mitochondrial-type CK and CK-MM isoforms were also lower (P<0.02, all analyses). Median mitochondria-sarcomere diffusion distances correlated well with CK to...
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to...
ObjectivesWe sought to determine to what extent systemic arterial compliance (SAC) might impact on a...
BackgroundAbnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to c...
Background: Why some but not all patients with severe AS (SevAS) develop otherwise unexplained ...
This thesis aims to better understand the metabolic dimension of cardiac adaptation to increased wor...
Mitochondrial creatine kinase (Mt-CK) is a major determinant of cardiac energetic status and is down...
Available online 01 February 2018Metabolic syndrome is a cluster of obesity-related metabolic abnorm...
Aortic stenosis (AS) remains the most common valvular disease in the elderly with an increasing prev...
Background: Mortality dramatically rises with the onset of symptoms in patients with severe aortic s...
Objectives In hypertension, low myocardial energetic efficiency (MEEi) has been documented as an int...
31P MR spectroscopy has become a valuable tool for assessment of alterations in myocardial high-ener...
Regulation of coronary blood flow is maintained through a delicate balance of ventriculoarterial and...
The creatine kinase (CK) system is thought to play an integral role in maintaining levels of chemica...
International audienceBackground: Abnormalities in cardiac energy metabolism occur in heart failure ...
BACKGROUND: Left ventricular (LV) hypertrophy in aortic stenosis (AS) is characterized by reduced my...
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to...
ObjectivesWe sought to determine to what extent systemic arterial compliance (SAC) might impact on a...
BackgroundAbnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to c...
Background: Why some but not all patients with severe AS (SevAS) develop otherwise unexplained ...
This thesis aims to better understand the metabolic dimension of cardiac adaptation to increased wor...
Mitochondrial creatine kinase (Mt-CK) is a major determinant of cardiac energetic status and is down...
Available online 01 February 2018Metabolic syndrome is a cluster of obesity-related metabolic abnorm...
Aortic stenosis (AS) remains the most common valvular disease in the elderly with an increasing prev...
Background: Mortality dramatically rises with the onset of symptoms in patients with severe aortic s...
Objectives In hypertension, low myocardial energetic efficiency (MEEi) has been documented as an int...
31P MR spectroscopy has become a valuable tool for assessment of alterations in myocardial high-ener...
Regulation of coronary blood flow is maintained through a delicate balance of ventriculoarterial and...
The creatine kinase (CK) system is thought to play an integral role in maintaining levels of chemica...
International audienceBackground: Abnormalities in cardiac energy metabolism occur in heart failure ...
BACKGROUND: Left ventricular (LV) hypertrophy in aortic stenosis (AS) is characterized by reduced my...
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to...
ObjectivesWe sought to determine to what extent systemic arterial compliance (SAC) might impact on a...
BackgroundAbnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to c...