Funder: MedImmune; doi: https://doi.org/10.13039/501100004628Abstract: Tissue stem cell exhaustion is a key hallmark of aging, and in this study, we characterised its manifestation in the distal lung. We compared the lungs of 3- and 22-month old mice. We examined the gross morphological changes in these lungs, the density and function of epithelial progenitor populations and the epithelial gene expression profile. Bronchioles became smaller in their cross-sectional area and diameter. Using long-term EdU incorporation analysis and immunohistochemistry, we found that bronchiolar cell density remained stable with aging, but inferred rates of bronchiolar club progenitor cell self-renewal and differentiation were reduced, indicative of an overal...
Abstract Background Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette ...
Cellular senescence is a cell fate decision and stress response that entails a permanent arrest of c...
In the aging lung, the lung capacity decreases even in the absence of diseases. The progenitor cells...
Funder: MedImmune; doi: https://doi.org/10.13039/501100004628Abstract: Tissue stem cell exhaustion i...
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the thir...
Pulmonary fibrosis is predominantly a disease of older adults. However, the processes underlying agi...
Different anatomic and physiological changes occur in the lung of aging people that can affect pulmo...
The effect of increased age on gene expression has not previously been evaluated in lung tissues. Ca...
AbstractTo determine whether aging is associated with a pro-inflammatory shift in the lung, inflamma...
Cellular senescence is now considered an important driving mechanism for chronic lung diseases, part...
Throughout life adult animals crucially depend on stem cell populations to maintain and repair their...
Lung fibrosis is increasingly detected with aging and has been associated with poor outcomes in acut...
Ageing is generally defined as the progressive decline of homeostasis that occurs after the reproduc...
Fibrotic lung diseases increase with age. Previously we determined that senescence increases tissue ...
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the thir...
Abstract Background Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette ...
Cellular senescence is a cell fate decision and stress response that entails a permanent arrest of c...
In the aging lung, the lung capacity decreases even in the absence of diseases. The progenitor cells...
Funder: MedImmune; doi: https://doi.org/10.13039/501100004628Abstract: Tissue stem cell exhaustion i...
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the thir...
Pulmonary fibrosis is predominantly a disease of older adults. However, the processes underlying agi...
Different anatomic and physiological changes occur in the lung of aging people that can affect pulmo...
The effect of increased age on gene expression has not previously been evaluated in lung tissues. Ca...
AbstractTo determine whether aging is associated with a pro-inflammatory shift in the lung, inflamma...
Cellular senescence is now considered an important driving mechanism for chronic lung diseases, part...
Throughout life adult animals crucially depend on stem cell populations to maintain and repair their...
Lung fibrosis is increasingly detected with aging and has been associated with poor outcomes in acut...
Ageing is generally defined as the progressive decline of homeostasis that occurs after the reproduc...
Fibrotic lung diseases increase with age. Previously we determined that senescence increases tissue ...
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the thir...
Abstract Background Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette ...
Cellular senescence is a cell fate decision and stress response that entails a permanent arrest of c...
In the aging lung, the lung capacity decreases even in the absence of diseases. The progenitor cells...