An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml