Da’wa (proselytization) is an important aspect of Islam Religion. It based on holybook (al-quran) and hadits as doctrine sources. Historically Islam has been developed around the world through da’wa. So, Islam is named as a da’wa religion. This article aims to describe da’wa practices and its challenges in Kotawaringin Timur Regency, Central Kalimantan, Indonesia. This research was conducted in Kotawaringin Timur Regency for some reasons . It is a strategic district because it is quite advanced both economically and infrastructure as well as the longstanding development of Islam.The data of article was collected by observation, depth interview, and documentation. By using descriptive qualitative methods, the study find out some findings, ...