For over a half-century the anti-malarial drug chloroquine (CQ) has been used as a therapeutic agent, alone or in combination, to treat autoimmune diseases. However, neither the underlying mechanism(s) of action nor their molecular target(s) are well defined. The orphan nuclear receptor Nurr1 (also known as NR4A2) is an essential transcription factor affecting the development and maintenance of midbrain dopaminergic neurons. In this study, using in vitro T cell differentiation models, we demonstrate that CQ activates TREG cell differentiation and induces Foxp3 gene expression in a Nurr1-dependent manner. Remarkably, CQ appears to induce Nurr1 function by two distinct mechanisms: firstly, by direct binding to Nurr1's ligand-binding domain an...
Background: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythemat...
Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) charact...
Background/Aims: Bitter-tasting chloroquine can suppress T cell activation by inhibiting Ca2+ signal...
For over a half-century the anti-malarial drug chloroquine (CQ) has been used as a therapeutic agent...
Background: The modulation of inflammatory processes is a necessary step, mostly orchestrated by reg...
Chloroquine (CQ) is widely used as an anti-inflammatory therapeutic for rheumatic diseases. Although...
achieved great success in controlling inflammation in several experimental models. Chloroquine (CQ)...
Thymic stromal lymphopoietin (TSLP) produced by mast cells is involved in allergic inflammation path...
Lipopolysaccharide(LPS) is a key pathogen for sepsis, and its recognition with toll-like receptor 4(...
AbstractThe nuclear receptor related-1 (Nurr1) protein plays an important role in both the developme...
<div><p>Nuclear receptor Nur77, also referred to as NR4A1 or TR3, plays an important role in innate ...
<p>Briefly, mice were treated with chloroquine via i.p. for five consecutive days. Three days after ...
IL-37 is a cytokine that plays critical protective roles in many metabolic inflammatory diseases, an...
Nuclear Receptors play key roles in cell differentiation and development, homeostasis and in many di...
Excessive synthesis and release of proinflammatory cytokines during endotoxemia causes severe pathop...
Background: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythemat...
Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) charact...
Background/Aims: Bitter-tasting chloroquine can suppress T cell activation by inhibiting Ca2+ signal...
For over a half-century the anti-malarial drug chloroquine (CQ) has been used as a therapeutic agent...
Background: The modulation of inflammatory processes is a necessary step, mostly orchestrated by reg...
Chloroquine (CQ) is widely used as an anti-inflammatory therapeutic for rheumatic diseases. Although...
achieved great success in controlling inflammation in several experimental models. Chloroquine (CQ)...
Thymic stromal lymphopoietin (TSLP) produced by mast cells is involved in allergic inflammation path...
Lipopolysaccharide(LPS) is a key pathogen for sepsis, and its recognition with toll-like receptor 4(...
AbstractThe nuclear receptor related-1 (Nurr1) protein plays an important role in both the developme...
<div><p>Nuclear receptor Nur77, also referred to as NR4A1 or TR3, plays an important role in innate ...
<p>Briefly, mice were treated with chloroquine via i.p. for five consecutive days. Three days after ...
IL-37 is a cytokine that plays critical protective roles in many metabolic inflammatory diseases, an...
Nuclear Receptors play key roles in cell differentiation and development, homeostasis and in many di...
Excessive synthesis and release of proinflammatory cytokines during endotoxemia causes severe pathop...
Background: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythemat...
Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) charact...
Background/Aims: Bitter-tasting chloroquine can suppress T cell activation by inhibiting Ca2+ signal...