Genome-wide association study of Parkinson’s disease in East Asians
- Foo, Jia Nee
- Tan, Louis C.
- Irwan, Ishak D.
- Au, Wing-Lok
- Low, Hui Qi
- Prakash, Kumar-M.
- Azlina Ahmad-Annuar
- Bei, Jinxin
- Chan, Anne Y. Y.
- Chen, Chiung Mei
- Chen, Yi-Chun
- Chung, Sun Ju
- Deng, Hao
- Lim, Shen-Yang
- Mok, Vincent
- Pang, Hao
- Pei, Zhong
- Peng, Rong
- Shang, Hui-Fang
- Song, Kyuyoung
- Tan, Ai Huey
- Wu, Yih-Ru
- Aung, Tin
- Cheng, Ching-Yu
- Chew, Fook Tim
- Chew, Soo-Hong
- Chong, Siow-Ann
- Ebstein, Richard P.
- Lee, Jimmy
- Saw, Seang-Mei
- Seow, Adeline
- Subramaniam, Mythily
- Tai, E-Shyong
- Vithana, Eranga N.
- Wong, Tien-Yin
- Heng, Khai Koon
- Meah, Wee-Yang
- Khor, Chiea Chuen
- Liu, Hong
- Zheng, Furen
- Liu, Jianjun
- Tan, Eng-King
DOIAbstract
Genome-wide association studies (GWAS) on Parkinson’s disease (PD) have mostly been done in Europeans and Japanese. No study has been done in Han Chinese, which make up nearly a fifth of the world population. We conducted the first Han Chinese GWAS analysing a total of 22,729 subjects (5,125 PD cases and 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China and Taiwan. We performed imputation, merging and logistic regression analyses of 2,402,394 SNPs passing quality control filters in 779 PD cases, 13,227 controls, adjusted for the first three principal components. 90 SNPs with association P 1.45) on PD risk. Our results also demonstrate some differences in the genetic contribution to PD between Europeans and Asians....
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