Glyphosate-based herbicide induces hyperplastic ducts in the mammary gland of aging Wistar rats
- Zanardi, Maria Victoria
- Guerrero Schimpf, Marlise Luciana
- Gastiazoro, Maria Paula
- Milesi, Maria Mercedes
- Muñoz de Toro, Monica Milagros
- Varayoud, Jorgelina Guadalupe
- Durando, Milena de Lourdes
DOIAbstract
Adverse effects of glyphosate-based herbicide (GBH) exposure on endocrine-related tissues have been reported. Our aim was to determine whether early postnatal exposure to a GBH produces long-term effects on the mammary gland. Female Wistar pups were injected with saline solution (Control) or GBH (2 mg glyphosate/kg/day) on postnatal days (PND) 1, 3, 5 and 7. At 20 months old, mammary gland and serum samples were collected. 17β-estradiol and progesterone serum levels were assessed. In the mammary gland, histomorphological features, proliferation index and steroid hormone receptors expression, by immunohistochemistry, were determined. GBH exposure produced morphological changes evidenced by a higher percentage of hyperplastic ducts and a fibr...
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