Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK) of several CYP3A substrates. We included 251 healthy volunteers who received a single dose of ambrisentan, atorvastatin, imatinib, aripiprazole, fentanyl, amlodipine, donepezil, olanzapine, fesoterodine, or quetiapine. The volunteers were genotyped for CYP3A4 and CYP3A5 polymorphisms by qPCR. To compare the PK across studies, measurements were corrected by the mean of each parameter for every drug and were logarithmically transformed. Neither CYP3A phenotype nor individual CYP3A4 or CYP3A5 polymorphisms were significantly associated with differences in PK. ...
In the field of pharmacokinetics, cytochrome P450 enzymes have been extensively studied. The CYP450 ...
<p><b>Introduction:</b> Co-medication, gene polymorphisms and co-morbidity are main causes for high ...
Almost half of prescription medications are metabolized by cyto-chrome P450 3A4 and 3A5. CYP3A4 and ...
Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We a...
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsibl...
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsibl...
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsibl...
Pharmacogenetics is the study of genetic variation that causes variation in drug levels (pharmacokin...
The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to ...
Pharmacogenetics is the study of genetic variation that causes variation in drug levels (pharmacoki...
CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with...
Background: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important det...
AbstractCytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and respon...
Cytochrome P450 enzymes, especially those of the CYP3A family, play a major role in the metabolism o...
Among the four cytochrome P450 (CYP)3A genes, CYP3A4 and CYP3A5 are the most abundantly expressed in...
In the field of pharmacokinetics, cytochrome P450 enzymes have been extensively studied. The CYP450 ...
<p><b>Introduction:</b> Co-medication, gene polymorphisms and co-morbidity are main causes for high ...
Almost half of prescription medications are metabolized by cyto-chrome P450 3A4 and 3A5. CYP3A4 and ...
Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We a...
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsibl...
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsibl...
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsibl...
Pharmacogenetics is the study of genetic variation that causes variation in drug levels (pharmacokin...
The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to ...
Pharmacogenetics is the study of genetic variation that causes variation in drug levels (pharmacoki...
CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with...
Background: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important det...
AbstractCytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and respon...
Cytochrome P450 enzymes, especially those of the CYP3A family, play a major role in the metabolism o...
Among the four cytochrome P450 (CYP)3A genes, CYP3A4 and CYP3A5 are the most abundantly expressed in...
In the field of pharmacokinetics, cytochrome P450 enzymes have been extensively studied. The CYP450 ...
<p><b>Introduction:</b> Co-medication, gene polymorphisms and co-morbidity are main causes for high ...
Almost half of prescription medications are metabolized by cyto-chrome P450 3A4 and 3A5. CYP3A4 and ...