Difference mid-IR nanospectroscopy on individual patches of purple membranes: The proton pump activity of bacteriorhodopsin at the nanoscale
- Giliberti V.
- Polito R.
- Ritter E.
- Broser M.
- Hegemann P.
- Puskar L.
- Schade U.
- Zanetti-Polzi L.
- Daidone I.
- Corni S.
- Rusconi F.
- Biagioni P.
- Baldassarre L.
- Ortolani M.
Publication date
January 2019
DOI Publisher
Institute of Electrical and Electronics Engineers (IEEE)Abstract
Conformational changes of the light-sensitive membrane receptor and proton pump bacteriorhodopsin is investigated by tip-enhanced mid-infrared nanospectroscopy on individual cell membrane patches, with a dramatic increase of sensitivity (in terms of number of probed molecules) compared with standard mid-infrared spectroscopy
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