The use of misoprostol and mifepristone in second trimester interruption of pregnancy. State of art

The therapeutic abortion is the voluntary interruption of the pregnancy after ninety days. This kind of abortion was introduced to preserve the mother’s health or to avoid the development of a fetus marked by malformations or serious illnesses. The pharmacological abortion induced by the drugs mifepristone and/or misoprostol represents the most commonly used procedure for medical intervention during pregnancy and is effective in 90% of cases. Second-trimester abortions account for 10- 15% of all abortions induced worldwide and are responsible for two-thirds of all major abortion-related complications. This article aims to provide basic information on the recommended regimes for second-trimester medical abortion and best management practices as targeted therapy is a stronghold in clinical practice with the aim of minimizing side effects and achieving maximum results