Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora
- Fiedler, Hans-Peter
- Bruntner, Christina
- Riedlinger, Julia
- Bull, Alan T.
- Knutsen, Gjert
- Goodfellow, Michael
- Jones, Amanda L.
- Maldonado, Luis A.
- Pathom-aree, Wasu
- Beil, Winfried
- Schneider, Kathrin
- Keller, Simone
- Sussmuth, Roderich D.
DOIAbstract
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines
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