We reconstruct the eruptive chronology of the Yucamane-Calientes compound volcano in southern Peru based on extensive fieldwork and a large dataset of geochronological (K-Ar, Ar-40/Ar-39, U-Pb, and C-14) and geochemical (major and trace element) analyses. This compound volcano is composed of two edifices that have experienced discontinuous volcanic activity from the middle Pleistocene to the Holocene. The Calientes volcano has been constructed in four successive stages: Calientes I is composed of andesitic lava flows dated at similar to 500 ka. Subsequently, the Callazas ignimbrite (Calientesll stage) was emplaced similar to 160-190 ka, followed by the main cone-building stage (Calientes Ill) at similar to 130-100 ka. Finally, the Holocene ...