Chronic neuropathic pain: It’s about the rhythm
- Alshelh, Z.
- Harrington, Flavia
- Youssef, A.M.
- Reeves, J.M.
- Macey, P.M.
- Russell Vickers, E.
- Peck, C.C.
- Murray, G.M.
- Henderson, L.A.
DOIAbstract
© 2016 The Authors. The neural mechanisms underlying the development and maintenance of chronic neuropathic pain remain unclear. Evidence from human investigations suggests that neuropathic pain is associated with altered thalamic burst firing and thalamocortical dysrhythmia. Additionally, experimental animal investigations show that neuropathic pain is associated with altered infra-slow (<0.1 Hz) frequency oscillations within the dorsal horn and somatosensory thalamus. The aim of this investigation was to determine whether, in humans, neuropathic pain was also associated with altered infra-slow oscillations within the ascending “pain” pathway. Using resting-state functional magnetic resonance imaging, we found that individuals with oro...
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