This paper reports on the results of an ongoing Research Project, funded by the Italian Civil Protection Department, aimed at the evaluation of the risk of collapse and usability-preventing performance levels for existing buildings. This paper, in particular, describes the results of nonlinear time-history analyses (NTHA) carried out on two different RC buildings retrofitted with isolation systems. The two buildings are located in two different sites, Naples and L’Aquila characterized by medium and high seismicity for Italy, and are designed for gravity loads only and according to outdated seismic codes respectively. The buildings have been retrofitted using three different isolation systems: (i) high damping rubber bearings; (ii) rubber be...