Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer cells has found to be crucial for cell survival, thus increased levels may trigger ferroptosis in HCC. In our study, we investigated the effect of different ROS modulators and ferroptosis inducers on a human HCC cell line and a human hepatoblastoma cell line. We identified a novel synergistic cell death induction by the combination of Auranofin and buthionine sulfoxime (BSO) or by Erastin and BSO at subtoxic concentrations. We ...
Iron, the fourth most abundant element in the Earth's crust, is vital in living organisms because of...
Understanding how cancer cells resist ferroptosis is a significant problem that impacts ongoing effo...
Currently, mechanisms and therapeutic approaches have been thoroughly studied in various prevalent m...
Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lip...
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis...
SummaryFerroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We ...
Liver cancer represents a global health challenge with worldwide growth. Hepatocellular carcinoma (H...
A non-apoptotic iron-dependent form of Regulated Cell Death (RCD) known as ferroptosis is brought on...
The publisher's final edited version of this article is available at Oncogene. 2018 Oct;37(40):5435-...
Ferroptosis, an iron and reactive oxygen species (ROS)-dependent non-apoptotic type of regulated cel...
Reactive oxygen species (ROS) are involved in various signalling mechanisms. Redox homeostasis is im...
Ferroptosis is a recently discovered iron dependent form of programmed cell death, characterized by ...
Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and iron-dependent li...
Hepatocellular carcinoma (HCC) is both a devastating and common disease. Every year in the United St...
Ferroptosis, a new mode of nonapoptotic cell death, is increasingly recognized as a new hope in over...
Iron, the fourth most abundant element in the Earth's crust, is vital in living organisms because of...
Understanding how cancer cells resist ferroptosis is a significant problem that impacts ongoing effo...
Currently, mechanisms and therapeutic approaches have been thoroughly studied in various prevalent m...
Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lip...
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis...
SummaryFerroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We ...
Liver cancer represents a global health challenge with worldwide growth. Hepatocellular carcinoma (H...
A non-apoptotic iron-dependent form of Regulated Cell Death (RCD) known as ferroptosis is brought on...
The publisher's final edited version of this article is available at Oncogene. 2018 Oct;37(40):5435-...
Ferroptosis, an iron and reactive oxygen species (ROS)-dependent non-apoptotic type of regulated cel...
Reactive oxygen species (ROS) are involved in various signalling mechanisms. Redox homeostasis is im...
Ferroptosis is a recently discovered iron dependent form of programmed cell death, characterized by ...
Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and iron-dependent li...
Hepatocellular carcinoma (HCC) is both a devastating and common disease. Every year in the United St...
Ferroptosis, a new mode of nonapoptotic cell death, is increasingly recognized as a new hope in over...
Iron, the fourth most abundant element in the Earth's crust, is vital in living organisms because of...
Understanding how cancer cells resist ferroptosis is a significant problem that impacts ongoing effo...
Currently, mechanisms and therapeutic approaches have been thoroughly studied in various prevalent m...