Add to ORKGRecent studies have shown that certain living cells are sensitive to low levels of contaminants from polymer containers. These bioprocessing containers (BPC) are fundamental in the growth of cellular materials using single-use type bioprocessing. Many vaccines and antibiotics are created using BPCs.1 Irgafos 168 is a stabilizing agent that is used in many BPCs. It is used because it is highly resistant to hydrolysis and it protects the polymer.2 This study will look at the impact of irgafos 168 and determine the toxicity of the contaminant and how much irgafos 168 differents components of the BPC (tubing, bags, connections) will leach. Multiple bioreactor runs will be used to measure the amount of contaminants leached from the BPCs
Plastic pollution is a source of chemical to the environment and wildlife. Despite the ubiquity of p...
International audiencePlastic pollution is a source of chemical to the environment and wildlife. Des...
This paper reports the chemical identity and mechanism of action and formation of a cell growth inhi...
A high-throughput cell-based assay (HT-CBA) was developed to investigate the impacts of the polymer ...
There is an upward trend in the use of disposable containers for manufacturing biopharmaceuticals. S...
Leachables from bioprocess containers (BPCs) are a source of process-related impurities that have th...
The biomanufacturing world has increasingly adopted single-use systems to achieve greater efficiency...
Single‐use technologies, in particular disposable bioreactor bags, have become integral within the b...
Extractable and leachable compounds are a major obstacle in the implementation of single-use technol...
Budde DL. Improvement of a cell-based test system for the biological assessment of plastics for use ...
peer-reviewedSingle‐use technologies, in particular disposable bioreactor bags, have become integral...
Single-use technologies (SUTs) are widely used during biopharmaceutical manufacture as disposable bi...
During the last decade, single-use bioreactors or storage vessels made of flexible bags have been we...
This paper reports the chemical identity and mechanism of action and formation of a cell growth inhi...
This presentation reports the chemical identity and mechanisms of action and formation of a single c...
Plastic pollution is a source of chemical to the environment and wildlife. Despite the ubiquity of p...
International audiencePlastic pollution is a source of chemical to the environment and wildlife. Des...
This paper reports the chemical identity and mechanism of action and formation of a cell growth inhi...
A high-throughput cell-based assay (HT-CBA) was developed to investigate the impacts of the polymer ...
There is an upward trend in the use of disposable containers for manufacturing biopharmaceuticals. S...
Leachables from bioprocess containers (BPCs) are a source of process-related impurities that have th...
The biomanufacturing world has increasingly adopted single-use systems to achieve greater efficiency...
Single‐use technologies, in particular disposable bioreactor bags, have become integral within the b...
Extractable and leachable compounds are a major obstacle in the implementation of single-use technol...
Budde DL. Improvement of a cell-based test system for the biological assessment of plastics for use ...
peer-reviewedSingle‐use technologies, in particular disposable bioreactor bags, have become integral...
Single-use technologies (SUTs) are widely used during biopharmaceutical manufacture as disposable bi...
During the last decade, single-use bioreactors or storage vessels made of flexible bags have been we...
This paper reports the chemical identity and mechanism of action and formation of a cell growth inhi...
This presentation reports the chemical identity and mechanisms of action and formation of a single c...
Plastic pollution is a source of chemical to the environment and wildlife. Despite the ubiquity of p...
International audiencePlastic pollution is a source of chemical to the environment and wildlife. Des...
This paper reports the chemical identity and mechanism of action and formation of a cell growth inhi...