Selection of Patient Specific Dosing Schemes for Procedures of Short Duration and Moderate Stimulation Utilizing Multiobjective Optimization Techniques

Modern anesthesia practice uses a combination of drugs to manage pain and sedation. There are often adverse or negative side effects that arise due to the same combination. A control system will be designed that optimizes the delivery of intravenous sedatives and analgesics to allow esophageal instrumentation while minimizing respiratory compromise and loss of responsiveness in spontaneously breathing patients. A cost functional will be developed to combine the multiple optimization goals into a single objective optimization problem. It is not possible to simultaneously optimize all criteria. A compromise solution must be selected. After selecting weighting coefficients, simulations were run and evaluated by the optimization function. The top five were plotted. The peaks for the five selected doses look reasonable. The maintenance infusions are probably too low for someone to tolerate a placed probe. Additional work is needed to investigate this. These results show promise for the development of a multiobjective optimization approach to patient-specific selection of dosing schemes