Minimizing Post-Surgery Wake-Up Time While Providing Adequate Analgesia

Alternative drug combinations are anesthetically equipotent but have different re-emergence and nociception outcomes. The perfect drug combination - causing a short post surgery wake up time and an extended time until pain - is dependent on the patient, surgical stimulus, and previous dosing. Our goal is to create a technique to find optimized drug dosings that lessens re-emergence time and extends nociception. Method - Use records from 20 general anesthestic procedures that involved Remifentanil and Propofol we calculated equipotent concentrations with more desirable results. Results - The optimization technique improved post surgery re-emergence time on average 5.22 minutes and lengthened nociception time on average 4.22, 7.55, and 9.84 minutes for the three different cases. Discussion - This technique fulfills its primary goal to find more optimal concentrations for anesthesia. The technique is capable of clinical practice to offer optimal suggestions to the anesthesiologist during surgery