Problem-based learning is an approach to education and learning that focuses on students investigating problems, rather than being directly instructed by teachers. Reviews, also called meta-analyses, comparing traditional lecture-based learning to problem-based learning report modest positive learning gains in student cognitive outcomes. Many meta-analyses have been conducted to analyze the effectiveness of problem-based learning, but none examine the extent of self-directed learning in problem-based learning. The purpose of this study was to conduct a meta-analysis across all disciplines (medicine, education, business, history, etc.) while examining self-directed learning in problem-based learning. This study used a random effects model me...