TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) have been classically considered as non-genotoxic compounds because they fail to be directly mutagenic in either bacteria or most in vitro assay systems. They do so in spite of having repeatedly been linked to oxidative stress and to mutagenic and carcinogenic outcomes. Oxidative stress, on the other hand, has been used as a marker for the toxicity of dioxin and its congeners. We have focused this review on the connection between oxidative stress induction and the toxic effects of fetal and adult dioxin exposure, with emphasis on the large species difference in sensitivity to this agent. We examine the roles that the dioxin-inducible cytochrom...
Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most...
Dioxins are ubiquitous and persistent environmental contaminants whose background levels are still r...
The arylhydrocarbon receptor (AhR) mediates toxicities of dioxins, including the most potent congene...
TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) h...
The science of toxicology is devoted, in large part, to understanding mechanisms of toxicity so that...
Dioxins and related compounds are common environmental contaminants. Although their levels have gone...
Dioxins are highly toxic and persistent halogenated organic pollutants belonging to two families i.e...
The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins -wides...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of enviro...
‘Dioxin-like’ (DL) compounds occur ubiquitously in the environment. Toxic responses associated with ...
The aryl hydrocarbon receptor (AhR) binds a wide range of structurally diverse compounds such as hal...
Dioxins are a family of molecules associated to several industrial accidents such as Ludwigshafen in...
Aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor-1alpha (HIF-1alpha) are conditionally r...
The aryl hydrocarbon receptor (AhR) mediates nearly all studied adverse effects of 2,3,7,8-tetrachlo...
The aryl hydrocarbon receptor is a signal regulated transcription factor that has best been characte...
Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most...
Dioxins are ubiquitous and persistent environmental contaminants whose background levels are still r...
The arylhydrocarbon receptor (AhR) mediates toxicities of dioxins, including the most potent congene...
TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) h...
The science of toxicology is devoted, in large part, to understanding mechanisms of toxicity so that...
Dioxins and related compounds are common environmental contaminants. Although their levels have gone...
Dioxins are highly toxic and persistent halogenated organic pollutants belonging to two families i.e...
The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins -wides...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of enviro...
‘Dioxin-like’ (DL) compounds occur ubiquitously in the environment. Toxic responses associated with ...
The aryl hydrocarbon receptor (AhR) binds a wide range of structurally diverse compounds such as hal...
Dioxins are a family of molecules associated to several industrial accidents such as Ludwigshafen in...
Aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor-1alpha (HIF-1alpha) are conditionally r...
The aryl hydrocarbon receptor (AhR) mediates nearly all studied adverse effects of 2,3,7,8-tetrachlo...
The aryl hydrocarbon receptor is a signal regulated transcription factor that has best been characte...
Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most...
Dioxins are ubiquitous and persistent environmental contaminants whose background levels are still r...
The arylhydrocarbon receptor (AhR) mediates toxicities of dioxins, including the most potent congene...