Add to ORKGCurrently, most of the commercially available therapeutics are all targeting cell surface receptors which constitutes only a small portion of the targets found in the cells. Therefore, reaching intracellular targets would provide many new opportunities to treat various diseases. However, intracellular delivery of therapeutic molecules has always been a challenge due to the poor permeability of cell membrane to large, negatively charged macromolecules and their restricted biodistribution. In the past decades, cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), are shown to improve the intracellular delivery of bioactive molecules and among the PTDs, arginine-rich peptides are highlighted as the most effective...
International audienceOne of the major challenges for new therapeutics molecules to enter the clinic...
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previousl...
AbstractProtein transduction domains (PTDs) are peptides that afford the internalization of cargo ma...
Currently, most of the commercially available therapeutics are all targeting cell surface receptors ...
The plasma membrane is a major obstacle in the development and use of biomacromolecules for intracel...
RNA interference is gaining attention as a means to explore new molecular pathways and for its poten...
Delivering functional proteins and antibodies into cells can allow researchers to probe the intracel...
Delivering peptides and proteins with intracellular function represents a promising avenue for thera...
A cell delivery system is increasing in use in many areas of cell and molecular biology and bio-medi...
Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoe...
A fundamental understanding of how polymer structure impacts internalization and delivery of biologi...
Intracellular protein delivery is an invaluable tool for biomedical research, as it enables fundamen...
Cell penetrating peptides (CPP), also known as protein transduction domains (PTD), are small peptide...
The direct intracellular delivery of proteins has, until recently, been difficult to achieve, due pr...
Proteins are primary targets in drug discovery. However, with a few rare exceptions, they are unable...
International audienceOne of the major challenges for new therapeutics molecules to enter the clinic...
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previousl...
AbstractProtein transduction domains (PTDs) are peptides that afford the internalization of cargo ma...
Currently, most of the commercially available therapeutics are all targeting cell surface receptors ...
The plasma membrane is a major obstacle in the development and use of biomacromolecules for intracel...
RNA interference is gaining attention as a means to explore new molecular pathways and for its poten...
Delivering functional proteins and antibodies into cells can allow researchers to probe the intracel...
Delivering peptides and proteins with intracellular function represents a promising avenue for thera...
A cell delivery system is increasing in use in many areas of cell and molecular biology and bio-medi...
Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoe...
A fundamental understanding of how polymer structure impacts internalization and delivery of biologi...
Intracellular protein delivery is an invaluable tool for biomedical research, as it enables fundamen...
Cell penetrating peptides (CPP), also known as protein transduction domains (PTD), are small peptide...
The direct intracellular delivery of proteins has, until recently, been difficult to achieve, due pr...
Proteins are primary targets in drug discovery. However, with a few rare exceptions, they are unable...
International audienceOne of the major challenges for new therapeutics molecules to enter the clinic...
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previousl...
AbstractProtein transduction domains (PTDs) are peptides that afford the internalization of cargo ma...