Untersuchungen zur Expression von P-Glycoprotein an Hirngewebsproben bei Patienten mit pharmacoresistenter Epilepsie

keine AngabenSlices of human cortical tissue from epilepsy surgery were investigated. This were patients with medically intractable epilepsy inspite of sufficient serum antiepileptic drug concentrations. The human P-Glycoprotein (P-Glycoprotein, MDR 1) is an ATP-driven transporter for hydrophobic drugs and causes multidrug resistance in cancer. P-Glycoprotein is localised in the endothelial cells of vessels of the brain and it contributions to the blood brain barrier (BBB), since some AEDs (antiepileptic drugs) are substrates of P-Glycoprotein they can not be effective due to the efflux transport. It is suggested that a medically intractable epilepsy on its own does not ineritably lead to an increased P-Glycoprotein expression , but it does in combination with focal cortical dysplasia