Add to ORKGBiomimetic agents are synthetic compounds devised to resemble structures and properties of natural biomolecules with the aim to solve complex human problems. Glycomimetics, nucleoside analogues (NAs) and modified oligonucleotides (MOs) represent biomimetic agents that have found various pharmacological applications and constitute the topic of the three main sections in which this PhD thesis has been organized. The design, the synthesis and then the biological evaluation of such molecules have been undertaken; in all cases the aim was the development of new agents with targeted pharmacological activity or improved biological selectivity in several medicinal chemistry contexts
From a historical perspective, no single class of organic compounds has shared the same impact on th...
For several decades, significant scientific interest has been dedicated to developing bioactive smal...
PósterBiological drugs include a wide range of medicinal products created by biological instead of c...
In the current PhD thesis novel synthetic routes were developed for the synthesis of new compounds w...
This thesis is focused on the study of the central role of chirality in different kind of molecular ...
L’impiego in campo farmacologico di peptidi bioattivi presenti in natura é ostacolato da numerosi sv...
A drug discovery program starts when a disease or clinical condition has no suitable drugs. In respo...
Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred...
INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising ...
Nowadays the better understanding of pathological mechanisms is strongly correlated with the evoluti...
This Ph.D. thesis is located in the medicinal chemistry research field. Peptides are among the most ...
Bioconjugation is the process of linking or connecting a biological molecule with another moiety. Th...
Biology-oriented-synthesis (BIOS), is a chemocentric approach to identifying structurally novel mole...
Deutsch: Die vorliegende Arbeit beinhaltet die kombinatorische Synthese sowie biomedizinische Aspekt...
This thesis work deals, principally, with the development of different chemical protocols ranging fr...
From a historical perspective, no single class of organic compounds has shared the same impact on th...
For several decades, significant scientific interest has been dedicated to developing bioactive smal...
PósterBiological drugs include a wide range of medicinal products created by biological instead of c...
In the current PhD thesis novel synthetic routes were developed for the synthesis of new compounds w...
This thesis is focused on the study of the central role of chirality in different kind of molecular ...
L’impiego in campo farmacologico di peptidi bioattivi presenti in natura é ostacolato da numerosi sv...
A drug discovery program starts when a disease or clinical condition has no suitable drugs. In respo...
Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred...
INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising ...
Nowadays the better understanding of pathological mechanisms is strongly correlated with the evoluti...
This Ph.D. thesis is located in the medicinal chemistry research field. Peptides are among the most ...
Bioconjugation is the process of linking or connecting a biological molecule with another moiety. Th...
Biology-oriented-synthesis (BIOS), is a chemocentric approach to identifying structurally novel mole...
Deutsch: Die vorliegende Arbeit beinhaltet die kombinatorische Synthese sowie biomedizinische Aspekt...
This thesis work deals, principally, with the development of different chemical protocols ranging fr...
From a historical perspective, no single class of organic compounds has shared the same impact on th...
For several decades, significant scientific interest has been dedicated to developing bioactive smal...
PósterBiological drugs include a wide range of medicinal products created by biological instead of c...