Time-resolved Monte Carlo simulation of photon migration in tissue phantom in relation to glucose sensing

Glucose sensing is of great importance nowadays. In this paper, we apply the Monte Carlo technique to simulate the effect of glucose on pulse propagation within a 4% Intralipid skin phantom. This effect is based on refractive index matching of Intralipid vesicles relative to surrounding liquid (water) if glucose is added. Time-of-flight profiles of femtosecond pulses (906 nm) passed through a 2-mm thick plain glass cuvette are registered by two detectors 0.3 mm in diameter with numerical apertures of 0.19 and 0.29. It is found that glucose levels within the physiological range (100-500 mg/dl) and 1000 mg/dl can be detected due to the effect of glucose on peak location and intensity, and width of the registered pulses.