Implications of nitrosative stress in apoptotic cascades mediated by pro-inflammatory cytokines in immature neurons
- Vaz, A. R.
- Leitão Silva, S.
- Barateiro, A.
- Fernandes, A.
- Falcão, A. S.
- Silva, R. F. M.
- Brito, M. A.
- Brites, D.
DOIAbstract
The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may produce neuropathological sequelae [4]. Therefore, the aim of the present study was to: (i) deepen characterize the mechanisms of neuronal apoptosis upon cytokine exposure in neuronal immature cells; and (ii) investigate the role of NO as a determinant.Funded by FCT-PPCDT/SAU-MMO/55955/2004 and FCT-PTDC/SAU-NEU/64385/2006 (to DB
Add to ORKG