Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

Franquelim, Henri G.
De-Sousa, Filipa F.
Veiga, A. Salomé
Santos, Nuno C.
Castanho, Miguel A. R. B.

Open link

Publication date

January 2011

DOI

10.1039/c1sm06553j

Publisher

Royal Society of Chemistry (RSC)

Journal

Soft Matter

Abstract

© The Royal Society of Chemistry 2011HIV-1 inhibitor sifuvirtide presents increased affinity for cationic dipalmitoylethyl-phosphatidylcholine (EDPPC) in contrast to viral/raft-mimicking (VRM) membranes. When associated to sifuvirtide, EDPPC-containing vesicles fuse with VRM vesicles. After fusion, the peptide co-localizes on VRM vesicles, indicating an effective delivery and concentration of sifuvirtide towards the viral and lipid raft vicinity.Fundação para a Ciência e a Tecnologia – Ministério do Ensino e Ciência (FCT-MES; Portugal

Extracted data

We use cookies to provide a better user experience.

Data Protection

Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

Abstract

Extracted data

Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

Abstract

Extracted data

Related items

Related items