Clinical genomics of the relationship between ADAMTS7 and coronary artery calcification and atherosclerosis

Aim: There are many coronary artery disease (CAD) cases in which the explanation for its development cannot be readily explained by traditional risk factors. The purpose of this study was to examine the data whether ADAMTS7 polymorphisms is related to the presence or severity of CAD.Methods: A systematic review of the literature was conducted to address the relationship between ADAMTS7 polymorphism and atherosclerosis.Results: Nine studies were evaluated that examined the relationship between ADAMTS7 and coronary atherosclerosis and 3 studies that examined the relationship between ADAMTS7 and coronary calcification. The single nucleotide polymorphs (SNPs) included rs3825807, rs79265682, rs1994016, rs4380028, for coronary atherosclerosis and rs7173743, rs3825807 and rs1994016 for coronary artery calcification. The most consistent evidence for an association with coronary artery stenosis on coronary angiogram was with ADAMTS7 rs3825807 risk allele A vs. control G, followed by rs4380028. ADAMTS7 SNP rs3825807 was consistently association with coronary artery calcification. ADAMTS7 was associated with CAD severity and adverse CAD prognosis.Conclusion: ADAMTS7 polymorphisms especially SNP rs4380028 allele has been consistently associated with CAD with ADAMTS7 rsrs4380028 being the next most strongly associated. ADAMTS7 warrants further exploration for a role in the pathogenesis of CAD