The screening and function study of risk factors and biomarkers for Leukoaraiosis in Chinese-Han population

脑白质疏松症(Leukoaraiosis，LA)，也被称作为脑白质损伤(whitematterlesions，WMLs)和脑白质高信号(whitematterhyperintensities，WMHs)，是一种广泛存在于老年人群中的神经影像现象。LA虽不表现出具体的临床症状，但也非良性无危害的。它会增加认知功能下降、步态异常和跌倒、抑郁、中风、痴呆和尿失禁，甚至死亡的发生风险。随着人口老龄化速度的加快，LA正成为全球重大的老年医学问题。在西方国家，科学家们发现LA具有较大的遗传力，其中存在大量的易感基因，然而LA的分子发病机制至今仍不可知。作为一个人口老龄化日益严重、老年人口如此众多的大国，中...Leukoaraiosis (LA), also called white matter lesions (WMLs) and white matter hyperintensities (WMHs), is a frequent neuroimaging finding commonly seen on magnetic resonance imaging brain scans of elderly people. Although it remains asymptomatic, LA is not considered to be benign, and it is showed to be related to a host of poor clinical outcomes and increases the risk of cognitive function declin...学位：理学博士院系专业：药学院_化学生物学学号：3232012015395