α-Amino Phosphonates as Catalysts in Michael Addition and Synthesis of Carnosine

有机小分子催化以其反应条件温和、不含金属、低毒、原子经济、类似酶催化等特点,成为近年来备受关注且发展迅速的一种不对称合成方法。随着不对称催化研究的不断深入，许多研究者发现脯氨酸及其衍生物在多种不对称催化中显示了非常好的催化效果。α-氨基膦酸是重要含磷结构化合物，具有许多重要的生理作用，如抗肿瘤活性、植物生长调节剂、除草、杀菌和抑制酶活性。而环化的α-氨基膦酸其化学结构与脯氨酸结构类似，也可能含有类似的功能。环化α-氨基膦酸酯合成比较简单共三步，原料便宜易得，总产率51％。本论文将其运用到不对称的Michael加成中取得了良好的效果，反应均能顺利完成，ee最高达96％，dr最高超过99:1。考虑...Recently, small organic molecules acting as catalysts in organic reactions has attracted much attention and become an asymmetric synthetic method rapidly. With the development of asymmetric research, proline and its analogues have become high effective catalysts in asymmetric organic reactions. The active compounds of α-aminophosphonates and their derivatives are important compounds possessing div...学位：理学硕士院系专业：化学化工学院_有机化学学号：1912005130183