Metabonomic Analysis Reveals Mechanisms for Both Renoprotection of Exendin-4 in Rats with Diabetic Kidney Disease and Adaptation of Microbacterium YLB-01 to High Pressure and Low Temperature

基于核磁共振（NMR）的代谢组学是一门新兴的“组学”学科，它将1H-NMR波谱检测技术和模式识别分析技术相结合，被广泛应用于疾病的早期诊断、病理机制、药物的药效评估、微生物环境胁迫适应性等研究。本论文应用基于NMR技术的代谢组学方法，研究艾塞那肽Exendin-4（胰高血糖素样肽-1（GPL-1）类药物）对糖尿病肾病（DKD）大鼠的肾功能保护机制以及深海沉积微杆菌YLB-01耐受高压低温的分子机制。 糖尿病肾病(DKD)发病机制尚不完全明确。最近的研究表明GLP-1类药物（如Exendin-4）可能通过改善代谢来抑制DKD的发生发展，但其作用机制并不明确。为了揭示Exendin-4保护DKD...Nuclear magnetic resonance (NMR)-based metabonomics approach is a newly emerging “omic” discipline with the integration of NMR technique and pattern recognition analysis. It can been widely used in the early diagnosis and pathological mechanism of disease, efficacy evaluatio of drugs, mechanism of extremophiles adapation to environmental stress. In this work, we applied NMR-based metabonomics anal...学位：理学硕士院系专业：化学化工学院_化学生物学学号：2052013115166