Study on Cp2TiCl-Catalyzed Radical Reactions for the Construction of Multifunctional Aza-Quarternary Carbons and 1-Azaspirocyclics

本论文在实验室已经发展的一氯二茂钛催化的酰胺型的Mannich反应的基础上，拓展了合成多官能化酮基酰胺的方法并将之应用于构建多官能化氮杂季碳，进而研究了1-氮杂螺环的构造方法。此外，配合实验室在光催化不对称反应方面的研究，合成了系列N，N’-双氧手性配体。本论文取得的主要成果有： 一、建立了使用Reformatsky试剂及烯基格氏试剂对环状酰亚胺加成开环制备多官能化酮基酰胺的方法并在此基础上探索了1-氮杂螺环的构造方法。具体包括： 1)以环内及环外酰亚胺为底物，以Reformatsky试剂及末端烯基格氏试剂为亲核试剂，制备了一系列多官能化酮基酰胺。2)以多官能化酮基酰胺为底物，采用一氯二茂...Based on our previously developed methodology of Cp2TiCl-catlayzed radical-type Mannich reaction, we expanded this methodology to construct aza quarternary carbons by preparation of multi-functional keto-amides as synthetic precursor. Subsequently, 1-azaspirocycles were constructed by further manipulations. In addition, to assist the study of asymmetric photocatalytic reations in our laboratory, w...学位：理学硕士院系专业：化学化工学院_有机化学学号：2052014115154