The Applications of Noble Metal Nanoparticles as Enzyme Mimics in Point-of-Care Testing

酶联免疫吸附反应（Enzyme-LinkedImmunosorbentAssay，ELISA）由于其高特异性、规范化操作及普适性等优点在免疫诊断、食品安全、毒品检测等方面得到广泛应用。目前，基于免疫反应的临床诊断等主要依赖于光学、电学、磁学等分析方法。但是这些检测手段一般均需大型仪器和专业操作人员，操作复杂，耗时久且费用昂贵。在发病率极高的今天，有必要发展一种操作简单、省时且成本低廉的便携检测技术。即时检测（point-of-caretesting，POCT）是一种顺应时代需求的检测技术，它能够现场进行检测并快速得到结果，指导医生对患者进行疾病早期诊断与治疗。 由于自然界中天然酶的生物源本性...Enzyme-linked immunosorbent assay (ELISA) is widely used in immunodiagnosis, food safety and drug testing because of its high specificity, the standardized operation and the universality. Currently, optical, electrochemical and magnetic signal based ELISA methods are the “gold standard” readout for bioanalysis. However, most of them suffer from the limitation of application in developing countrie...学位：理学硕士院系专业：化学化工学院_分析化学学号：2052013115155