Development and application of antigenicity analytical methods for characterization high-risk HPV (HPV16/18/52/58) recombinant virus-like particle based vaccines

人乳头瘤病毒（HumanPapillomavirus，HPV）是属于乳多孔病毒科的球形DNA病毒，研究已证实该病毒与多种癌症密切相关，包括女性宫颈癌、阴道癌及男性阴茎癌等。该病毒主要衣壳蛋白L1可在体外自组装成病毒样颗粒（Virus-likeparticle，VLP），高度模拟天然病毒表面结构，并可通过类似途径刺激机体并诱导机体产生免疫应答。因此，基于重组VLP的HPV疫苗研发及应用具有极大潜力和重要价值。目前，由本实验室与厦门万泰公司联合研发的重组VLP人乳头瘤九价疫苗（HPV6/11/16/18/31/33/45/52/58疫苗）已经完成报批即将进入临床阶段。因而，建立针对该疫苗质量分析方...Human papilloma virus (HPV) is a spherical DNA virus belong to Papovaviridae family, many studies has confirmed that the virus is responsible for a variety of cancers, including women cervical cancer, vaginal cancer and penis carcinoma.The major capsid protein of HPV could self-assemble into recombinant virus-like particles (VLP), faithfully mimicing the structures of native virions, and they can ...学位：医学硕士院系专业：公共卫生学院_公共卫生硕士学号：3262014115056