Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole

以苯肼、乙酰乙酸乙酯和氨基杂环为原料 ,合成了两类含双杂环的新型吡唑甲酰胺衍生物 ,其结构经元素分析、1HNMR ,MS及IR确证 .初步的生物活性测试结果表明 :部分化合物对水稻纹枯病菌、小麦赤霉病菌和苹果轮纹病菌具有良好的抑制效果 .In order to search for novel fungicides with high activity and low toxicity, a series of bis-heterocyclic compounds containing 1H-pyrazole and thiazole were designed and synthesized from phenyl hydrazine, ethyl acetoacetate and aromatic aminoheterolcycles. The structures of all new compounds were confirmed by elemental analysis, 1H NMR, IR and MS spectra. Preliminary bioassays indicated that some compounds showed fungicidal activity against Pellicularia sasakii, Gibberella zeave and Physalospora piricola.科技部国家“九五”重点科技攻关 (No .97 563 0 2 0 5)资助项