Identification of four immune subtypes characterized by distinct composition and functions of tumor microenvironment in intrahepatic cholangiocarcinoma
- Job, Sylvie
- Rapoud, Delphine
- dos Santos, Alexandre
- Gonzalez, Patrick
- Desterke, Christophe
- Pascal, Gérard
- Elarouci, Nabila
- Ayadi, Mira
- Adam, René
- Azoulay, Daniel
- Denis, Castaing
- Vibert, Eric
- Cherqui, Daniel
- Samuel, Didier
- Sa Cuhna, Antonio
- Marchio, Agnès
- Pineau, Pascal
- Guettier, Catherine
- de Reyniès, Aurélien
- Faivre, Jamila
DOIAbstract
International audienceIntrahepatic cholangiocarcinoma (ICC) is asevere malignant tumor in which the standard therapies are mostly ineffective. The biological significance of the desmoplastic tumor microenvironment (TME) of ICC has been stressed, but was insufficiently taken into account in the search for classifications of ICC adapted to clinical trial design. We investigated the heterogeneous tumor stroma composition and built a TME-based classification of ICC tumors, which detects potentially targetable ICC subtypes
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