Reining in H2O2 for Safe Signaling

Refers to : Hyun Ae Woo, Sun Hee Yim, Dong Hae Shin, Dongmin Kang, Dae-Yeul Yu, Sue Goo Rhee (2010). Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling Cell, 140 (4), 517-528International audienceMammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site