Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that function as key signal transducers of a wide spectrum of extracellular stimuli, including growth factors and pro-inflammatory cytokines. Dysregulation of the extracellular signal-regulated kinase (ERK) MAPK pathway is associated with human skeletal abnormalities including Noonan syndrome, neurofibromatosis type 1, and cardiofaciocutaneous syndrome. Here, we demonstrate that ERK activation in osteoprogenitors is required for bone formation during skeletal development and homeostasis. Deletion of Mek1 and Mek2, kinases upstream of ERK MAPK, in osteoprogenitors (Mek1OsxMek2-/-), resulted in severe osteopenia and cleidocranial dysplasia (CCD), similar to that seen in...
RUNX2, a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and p38 MAP...
Bone continuously remodels throughout life by coordinated actions of osteoclasts and osteoblasts. Ab...
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix depositi...
Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that function as key signa...
The ERK/MAP kinase pathway is an important regulator of gene expression and differentiation in postm...
The extracellular signal-regulated kinases (ERK1 and 2) are widely-expressed and they modulate proli...
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix depositi...
Runx2 is a key transcription factor regulating osteoblast differentiation and skeletal morphogenesis...
<p><b><i>Overview</i></b>: The use of pro-osteogenic growth factors, such as BMP2, in human adipose-...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137207/1/jcp25517.pdfhttps://deepblue....
Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2 express...
AMPKα2 is a catalytic subunit of AMPK, which is a key regulator for cellular and whole body energy h...
Human umbilical cord mesenchymal stem cells (hUCMSCs) are recognized as candidate progenitor cells f...
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as oste...
The skeleton is a highly dynamic tissue whose structure relies on the balance between bone depositio...
RUNX2, a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and p38 MAP...
Bone continuously remodels throughout life by coordinated actions of osteoclasts and osteoblasts. Ab...
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix depositi...
Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that function as key signa...
The ERK/MAP kinase pathway is an important regulator of gene expression and differentiation in postm...
The extracellular signal-regulated kinases (ERK1 and 2) are widely-expressed and they modulate proli...
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix depositi...
Runx2 is a key transcription factor regulating osteoblast differentiation and skeletal morphogenesis...
<p><b><i>Overview</i></b>: The use of pro-osteogenic growth factors, such as BMP2, in human adipose-...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137207/1/jcp25517.pdfhttps://deepblue....
Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2 express...
AMPKα2 is a catalytic subunit of AMPK, which is a key regulator for cellular and whole body energy h...
Human umbilical cord mesenchymal stem cells (hUCMSCs) are recognized as candidate progenitor cells f...
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as oste...
The skeleton is a highly dynamic tissue whose structure relies on the balance between bone depositio...
RUNX2, a key transcription factor for osteoblast differentiation, is regulated by ERK1/2 and p38 MAP...
Bone continuously remodels throughout life by coordinated actions of osteoclasts and osteoblasts. Ab...
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix depositi...