This study investigates the potential for hydrothermal alteration and circulation in lava domes using combined analytical, remote sensing and numerical modeling approaches. This has been accomplished in three parts: 1) A comprehensive field, geochemical and remote sensing investigation was undertaken of the hydrothermal system in the Santiaguito lava dome complex in Guatemala. The Santiaguito domes were found to contain mainly hydrous silica alteration, which is unlikely to weaken dome rock, but the summit of Santa Maria was found to contain pervasive argillic alteration (clay minerals), which do pose more of a collapse-related hazard. These results were confirmed by hot spring geochemistry which indicated that water in the domes was respon...