Asthma in children and adolescents is a heterogeneous syndrome comprised of multiple poorly-defined subgroups with variable disease expression and response to environmental exposures (e.g. environmental tobacco smoke [ETS], vitamin D, allergens). ETS exposure induces a respiratory epithelial response that is mediated in part by oxidative stress. Although the mechanism behind this epithelial response is not completely understood, asthmatic respiratory epithelium appears to be more susceptible. Vitamin D has been shown to be positively associated with pulmonary function. Additionally, there is an emerging consensus that vitamin D deficiency increases risk of acute respiratory tract infections and might also increase the severity of chronic as...
Background: Asthma, a common lung disease in children, is caused by excessive immune responses to en...
Rationale: Exposure to outdoor air pollution has been associated with adverse respiratory effects in...
Rationale: Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asth...
BACKGROUND: Pathway analyses can be used to determine how host and environmental factors contribute ...
Background: Polymorphic markers of vitamin D pathway genes have been associated with asthma traits i...
About 23 million people, including almost 10 million children, have asthma in the United States. Ast...
Asthma is a globally significant non-communicable disease with major public health consequences for ...
About 23 million people, including almost 10 million children, have asthma in the United States. Ast...
Abstract Background Prior evidence suggests that vitamin D deficiency may increase the risk of asthm...
Background. 25-hydroxyvitamin D [25(OH)D] deficiency seems to be related to the development of asthm...
Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children w...
Asthma is a chronic inflammatory airway disease and both environmental and genetic factors contribut...
online supplementInternational audienceBACKGROUND: Delineating asthma subphenotypes is of interest t...
[[abstract]]Background Adult asthma is phenotypically heterogeneous with unclear aetiology. We aimed...
editorial reviewedIntroduction Eosinophilic asthma is well recognized asthma phenotype associated w...
Background: Asthma, a common lung disease in children, is caused by excessive immune responses to en...
Rationale: Exposure to outdoor air pollution has been associated with adverse respiratory effects in...
Rationale: Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asth...
BACKGROUND: Pathway analyses can be used to determine how host and environmental factors contribute ...
Background: Polymorphic markers of vitamin D pathway genes have been associated with asthma traits i...
About 23 million people, including almost 10 million children, have asthma in the United States. Ast...
Asthma is a globally significant non-communicable disease with major public health consequences for ...
About 23 million people, including almost 10 million children, have asthma in the United States. Ast...
Abstract Background Prior evidence suggests that vitamin D deficiency may increase the risk of asthm...
Background. 25-hydroxyvitamin D [25(OH)D] deficiency seems to be related to the development of asthm...
Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children w...
Asthma is a chronic inflammatory airway disease and both environmental and genetic factors contribut...
online supplementInternational audienceBACKGROUND: Delineating asthma subphenotypes is of interest t...
[[abstract]]Background Adult asthma is phenotypically heterogeneous with unclear aetiology. We aimed...
editorial reviewedIntroduction Eosinophilic asthma is well recognized asthma phenotype associated w...
Background: Asthma, a common lung disease in children, is caused by excessive immune responses to en...
Rationale: Exposure to outdoor air pollution has been associated with adverse respiratory effects in...
Rationale: Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asth...