The objectives of this research were to evaluate management options for tobacco thrips, Frankliniella fusca (Hinds), and reniform nematode, Rotylenchulus reniformis (Linford & Oliverira), in cotton productions systems. When evaluating tillage practices for pest control, conservational tillage reduced thrips densities and damage, while the impact on nematode densities is less understood and in this study had no impact. Insecticide seed treatments remain a vital resource for controlling thrips in Mid-South cotton production systems. When incorporating an early season herbicide application for weed control, systems with an insecticide seed treatment generally tolerated herbicide injury better than those with early season stress from thrips and...