Beta-cyclodextrin

Supercritical carbon dioxide (scCO(2)) offers several attractive scenarios for the pharmaceutical processing as an alternative to aqueous and organic solvents. In this work naproxen, a widely used non steroidal anti-inflammatory drug with analgesic and anti-inflammatory properties, was chosen as a model drug. Its complexation with cyclodextrins improves the rate and extent of dissolution of the drug, increase its rate of absorption and may reduce the unpleasant side-effects of the drug. The interest in using this supercritical technology led us to develop an experimental unit for the use of supercritical CO2 as a processing medium for the complexation of naproxen with beta cyclodextrin (CD)