Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells
- Ramalho, Rita M.
- Borralho, Pedro M.
- Castro, Rui E.
- Sola, Susana
- Steer, Clifford J.
- Rodrigues, Cecilia M. P.
Publication date
January 2006
DOI Publisher
Wiley ISSN
0022-3042 Journal
Journal of Neurochemistry Citation count (estimate)
41Abstract
Early onset familial Alzheimer's disease (FAD) is linked to autosomal dominant mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PS1 and PS2) genes. These are critical mediators of total amyloid beta-peptide (A beta) production, in
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