Robust Off- and Online Separation of Intracellularly Recorded Up and Down Cortical States
- Seamari, Yamina
- Narváez, José Ángel
- Vico-Vela, Francisco Jose
- Lobo Fernández, Daniel
- Sánchez Vives, María Victoria
Publication date
January 2007
DOI Publisher
Public Library of Science (PLoS)Abstract
Background. The neuronal cortical network generates slow (<1 Hz) spontaneous rhythmic activity that emerges from the recurrent connectivity. This activity occurs during slow wave sleep or anesthesia and also in cortical slices, consisting of alternating up (active, depolarized) and down (silent, hyperpolarized) states. The search for the underlying mechanisms and the possibility of analyzing network dynamics in vitro has been subject of numerous studies. This exposes the need for a detailed quantitative analysis of the membrane fluctuating behavior and computerized tools to automatically characterize the occurrence of up and down states. Methodology/Principal Findings. Intracellular recordings from different areas of the cerebral cort...
Add to ORKG